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・ RNA silencing
・ RNA spike-in
・ RNA splicing
・ RNA thermometer
・ RNA Tie Club
・ RNA transfection
・ RNA triphosphatase
・ RNA uridylyltransferase
・ RNA virus
・ RNA world
・ RNA-3'-phosphate cyclase
・ RNA-based evolution
・ RNA-binding protein
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・ RNA-dependent RNA polymerase
RNA-Directed DNA Methylation
・ RNA-induced silencing complex
・ RNA-induced transcriptional silencing
・ RNA-OUT
・ RNA-Seq
・ RNA22
・ RNAD Broughton Moor
・ RNAD Coulport
・ RNAD Trecwn
・ RNAF
・ RNAI
・ RNAi Global Initiative
・ RNAi-Based Identification System and interference of Specific Cancer Cells
・ RNAIII
・ RNAL


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RNA-Directed DNA Methylation : ウィキペディア英語版
RNA-Directed DNA Methylation

RNA-directed DNA methylation (RdDM) is an epigenetic process first discovered in plants (''Wassenegger et al'', 1994, Cell, Vol 76, 567-576). During RdDM, double-stranded RNAs (dsRNAs) are processed to 21-24 nucleotide small interfering RNAs (siRNAs) and guide methylation of homologous DNA loci. In plants dsRNAs may be generated from three sources:
* Viral replication intermediates
* Products of the endogenous RNA-directed RNA polymerase
* Transcribed inverted repeats
* Transposable elements
Besides RNA molecules, a plethora of proteins are involved in the establishment of RdDM, like Argonautes, DNA methyltransferases, chromatin remodelling complexes and the plant-specific PolIV and PolV. All these act in concert to add a methyl-group at the 5' position of cytosines. In contrast to animals, cytosines at all sequence context (CG, CHG, CHH) may get de novo methylated in plants.
==References==

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抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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